The Raabe Laboratory is seeking a highly motivated Research Specialist II to lead the development of new therapeutics targeting metabolic regulation of epigenetic drivers in aggressive pediatric brain tumors. Our laboratory has developed a unique niche in childhood cancer research at the cross-section of drug development, cancer metabolomics, and epigenetics. The research specialist will develop new reagents to target the abnormal epigenetics of pediatric brain tumors and will test the in vitro and in vivo efficacy of novel therapeutics in patient-derived cell models and mouse xenografts of pediatric brain tumors.
The Raabe Laboratory exists within the larger Eye and Brain Tumor Research Laboratory in the State-of-the-Art Smith Research Building and is part of the Oncology Department at Johns Hopkins. This position requiresexperience in laboratory techniques in molecular biology, biomedical engineering, animal studies, and tissue culture.
Specific Duties & Responsibilities:
Develops experimental designs and has primary responsibility for planning, implementation, evaluation and interpretation results; design process may be in collaboration with the PI or completed independently.
Identifies problems, troubleshoots and analyzes variations observed and reported in regular testing protocols; modifies, refines or adapts techniques and procedures; modifies and/or adjusts quality control measures.
Coordinates and/or conducts multiple, concurrent assignments or a multi-faceted project.
Compiles, analyzes, and interprets research data. Monitors documentation of results; reviews and recognizes documentation, which may lead to modification and adaptation of research methodologies; may collaborate with others; Adapts and/or modifies experimental methods based upon interpretation of data.
Conducts library research and participates in editing and preparing manuscripts, scientific illustrations, and computer graphics for publication.
Oversees and assures laboratory compliance with regulatory requirements and JHU standards, policies and procedures.
Works with research staff to prioritize and schedule projects.
Minimum Qualifications (Mandatory):
BS/BA in Biological Sciences, Chemistry or related field
Master's Degree in Biotechnology, preferred
Minimum of 2 years' laboratory experience performing relevant techniques in a comparable setting
Advanced Degree may substitute for experience to the extent permitted by the JHU equivalency formula.*
*JHU Equivalency Formula: 18 graduate degree credits (semester hours) may substitute for one year of experience. For jobs where equivalency is permitted, up to two years of non-related college course work may be applied towards the total minimum education/experience required for the respective job.
** Applicants who do not meet the posted requirements but are completing their final academic semester/quarter will be considered eligible for employment and may be asked to provide additional information confirming their academic completion date.
Special Knowledge, Skills & Abilities:
Culture and analysis of cell lines, immunohistochemistry, western blot.
Performing established laboratory assays under the supervision of the faculty investigator.
Operation of centrifuge, pH meter, analytical balance, incubator, spectrophotometer, light microscope, imaging systems and laminar flow hoods.
Familiarity with aseptic technique.
Familiarity with theory behind experiments; ability to apply analytical skills to interpret experiments using positive and negative controls.
Classified Title: Research Specialist II Role/Level/Range: ACRP/03/MB Starting Salary Range: Commensurate with experience Employee group: Full Time Schedule: M-F 8am-4:30pm Exempt Status: Exempt Location: School of Medicine Campus Department name: SOM Onc Pediatric Oncology Personnel area: School of Medicine
The successful candidate(s) for this position will be subject to a pre-employment background check.
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