The Analytical Pharmacology Shared Resource (APSR) within the Sidney Kimmel Cancer Center at Johns Hopkins is seeking a SR. Research Specialist to conduct and oversee bioanalytical chemistry experiments independently under direction of the laboratory director. The APSR provides high-quality clinical pharmacokinetic research in both clinical trials, pre-clinical experiments and drug discovery screening at Johns Hopkins. The APSR serves as the bioanalytical and clinical pharmacology facility for the Sidney Kimmel Cancer Center at Johns Hopkins, the Mid-Atlantic Shared Resources Consortium (Georgetown, University of Maryland, University of Virginia and the SKCCC), the Johns Hopkins Tuberculosis Research Advancement Center, and the Johns Hopkins Institute for Clinical and Translational Research Drug Discovery Development Core. We also serve as the reference laboratory for the AIDS Malignancy Consortium and as one of the two funded U24 Pharmacokinetics Centers for the ETCTN Pharmacokinetic Resource Laboratories.
The successful candidate must demonstrate the ability to collaborate and possess extensive and exceptional technical and scientific skills in advanced mass spectrometry and related technologies. The individual must have previously demonstrated the ability to successfully manage the various operational aspects of a multi-instrument high volume analytical chemistry facility. This individual will work closely with multiple research scientists to ensure accurate, relevant and reproducible data is being generated. This candidate must demonstrate knowledge and concepts of QC/QA as well as familiarity with analytical software. This position will be filled by a person who will be responsible for the development of new analytical methods and for troubleshooting analytical methods and instrumentation. The position requires the development of standard operating procedures, preparation of detailed reports, and diligent documentation skills. Additionally, the person will oversee center personnel and be responsible for training and mentoring new hires.
Specific Duties & Responsibilities
Design and develop specialized mass spectrometry analysis (LC/MS/MS and LC/IMS/MS/MS) techniques that can be utilized by APSR staff.
Handling and sample preparation involving biological samples (i.e., plasma, tissue, urine, etc.), and reagents for LC/MS/MS analysis to be completed independently or in collaboration with the APSR staff.
Maintain a level of scientific skill and/or knowledge and keeps up with current developments and trends in the area of mass spectrometry.
Compiles, analyzes, and interprets data processing methods and reports using specialized computer software applications.
Operation of LC/MS/MS systems including tune and calibrate on a regular basis and archive the reports.
Provide basic instrument maintenance mass spectrometer (clean curtain plate, change electrodes, vent and clean up to Q0 as needed) and LC systems (replace needles if damaged). For more complex instrument repairs, must be able to work closely with vendors to complete repairs.
Coordinate instrument service and PMs and work closely with field service engineers to maintain and adjust processes as needed for longevity of the laboratory equipment.
Collaborate with internal multidisciplinary teams to ensure both timeliness and accuracy of studies and regulatory requirements are met.
Prepare, review and review Standard Operating Procedures (SOPs).
Monitors documentation of all procedures, material, and results in compliance with applicable regulatory standards as applicable (protocols, methods, SOPs, etc.).
Oversees the completion of laboratory investigations. Perform daily assessment and assay troubleshooting, quality observations, and problem solving of technical and/or regulatory issues with minimal oversight.
Ensure that chemical inventory associated with lab instrumentation is updated: create, track, order and update lab-wide orders.
Oversees and/or conducts multiple, concurrent assignments or a multi-faceted project.
Perform administrative duties such as preparing monthly billing for equipment usage, special projects, and maintaining notebooks.
Contribute to and maintain lab operations.
Uses advanced knowledge base to author/co-author publications.
Assist APSR Director by reviewing sections of grant proposals as it pertains to specialized mass spectrometry knowledge.
Ensure compliance with quality control analytical testing guidelines.
Oversees and assures laboratory compliance with regulatory requirements and JHU standards, policies and procedures.
Provides training and mentoring to research staff and new hires.
Collaborates with the research staff to prioritize and schedule projects.
Performs other job-related duties as requested.
Bachelor's Degree in Biology, Chemistry or related field.
Six years experience in a comparable laboratory performing relevant techniques.
Additional education may substitute for experience to the extent permitted by the JHU equivalency formula.
Must possess strong hands-on experience with different chromatographic separation and mass spectrometry methodologies for analysis of biomarkers or small molecules.
Must have experience using LC/MS-compatible sample preparation methods such as protein precipitation, LLE and SPE, and enzymatic digestion.
Special Knowledge Skills & Abilities
Full understanding of regulatory and GLP requirements, industry standards and laboratory SOPs.
Fosters team-based approach to research. Committed to working synergistically and harmoniously with others.
Ability to work efficiently and multitask in a fast-paced environment is a must.
Experience in handling and processing human samples under BSL2/BSL3 environment.
Master's Degree a plus. Comparable laboratory experience may be substituted for educational requirement.
Experience in working in a GLP laboratory is highly desirable.
Classified Title: Sr. Research Specialist II Role/Level/Range: ACRP/04/ME Starting Salary Range: $62,780 - $86,390 (Commensurate with experience) Employee group: Full Time Schedule: M-F 8:30am- 5pm Exempt Status: Exempt Location: School of Medicine Campus Department name: SOM Onc Analytical Pharmacology Core Personnel area: School of Medicine
Please refer to the job description above to see which forms of equivalency are permitted for this position. If permitted, equivalencies will follow these guidelines:
30 undergraduate degree credits (semester hours) or 18 graduate degree credits may substitute for one year of experience. Additional related experience may substitute for required education on the same basis. For jobs where equivalency is permitted, up to two years of non-related college course work may be applied towards the total minimum education/experience required for the respective job.
The successful candidate(s) for this position will be subject to a pre-employment background check.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
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The pre-employment physical for positions in clinical areas, laboratories, working with research subjects, or involving community contact requires documentation of immune status against Rubella (German measles), Rubeola (Measles), Mumps, Varicella (chickenpox), Hepatitis B and documentation of having received the Tdap (Tetanus, diphtheria, pertussis) vaccination. This may include documentation of having two (2) MMR vaccines; two (2) Varicella vaccines; or antibody status to these diseases from laboratory testing. Blood tests for immunities to these diseases are ordinarily included in the pre-employment physical exam except for those employees who provide results of blood tests or immunization documentation from their own health care providers. Any vaccinations required for these diseases will be given at no cost in our Occupational Health office.
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