We are seeking a Lead Analytical Chemist who will work as part of the team in the Department of Oncology Analytical Pharmacology Core Laboratory (APC). The main focus of this laboratory is to determine the concentration of drugs and their metabolites in blood and tissue from clinical or preclinical experiments. This position will be filled by a person who will be responsible for the development of new analytical methods for drugs in development and for troubleshooting analytical methods and instrumentation.
Specific Duties & Responsibilities
Contributes to the development of new LC/MS methods, validation, extraction and analysis for drugs in development (e.g., ~75% novel compounds) from various biological matrices (plasma and tissue) to determine drug concentrations used in pharmacokinetic studies (e.g., how the drug is handled by the body.
Execute and interpret validation studies of small molecule drugs: selectivity, reproducibility, stability.
Has responsibility for performing daily assessment and troubleshooting of the LC/MS and other analytical instruments and equipment to identify the need for repair; maintain quality control for procedures and function checks on equipment.
Conducts multiple, concurrent assignments or a multi-faceted project. Experiments will include techniques in analytical chemistry (HPLC, LC/MS/MS), protein binding and drug metabolism.
Be willing to work with infectious (i.e. HIV positive) clinical samples and radioactive samples.
Compiles, analyzes, and interprets research data using specialized computer software applications.
Maintains biospecimen database and freezer inventory.
Contribute to writing of scientific publications and grant applications
Prepare and revise Assay Validation and Analytical Data Reports and SOPs developed in the laboratory.
Assures laboratory compliance with regulatory requirements and JHU standards, policies and procedures.
Act as a resource for laboratory techniques for post-doctoral fellow and students and junior technicians.
Provide back-up assistance with required safety-related procedures, including weekly wipe tests for radiation safety monitoring, periodic lab cleanup, etc.
Evaluate resources and determine research priorities when making decisions.
Performs related work as assigned.
Bachelor's Degree in Biology, Chemistry or related field.
Four years experience in a comparable laboratory performing relevant techniques.
Master's degree, with related graduate research, may substitute for experience to the extent permitted by the JHU equivalency formula.
*Applicants who do not meet the posted requirements but are completing their final academic semester/quarter will be considered eligible for employment and may be asked to provide additional information confirming their academic completion date.
Equipment, Machine, or Tool Requirements
Daily use of LC/MS instrumentation.
Intermittent use of general laboratory instrumentation including but not limited to centrifuges, solid-phase extraction manifolds, lyophilizer, evaporator, balances, pH meter, shaker, water bath, chemical fume hood, and biological cabinet.
General computer skills, with experience with Microsoft Office.
Classified Title: Sr. Research Specialist Working Title: Lead Analytical Chemist
Role/Level/Range: ACRP/04/MC Starting Salary Range: $46,560-$64,100 (commensurate with experience) Employee group: Full Time Schedule: M-F 8:30am- 5:00pm Exempt Status: Exempt Location: School of Medicine Campus Department name: SOM Onc Analytical Pharmacology Core Personnel area: School of Medicine
Please refer to the job description above to see which forms of equivalency are permitted for this position. If permitted, equivalencies will follow these guidelines: 30 undergraduate degree credits (semester hours) or 18 graduate degree credits may substitute for one year of experience. Additional related experience may substitute for required education on the same basis. For jobs where equivalency is permitted, up to two years of non-related college course work may be applied towards the total minimum education/experience required for the respective job.
The successful candidate(s) for this position will be subject to a pre-employment background check.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
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The following additional provisions may apply, depending on campus. Your recruiter will advise accordingly.
The pre-employment physical for positions in clinical areas, laboratories, working with research subjects, or involving community contact requires documentation of immune status against Rubella (German measles), Rubeola (Measles), Mumps, Varicella (chickenpox), Hepatitis B and documentation of having received the Tdap (Tetanus, diphtheria, pertussis) vaccination. This may include documentation of having two (2) MMR vaccines; two (2) Varicella vaccines; or antibody status to these diseases from laboratory testing. Blood tests for immunities to these diseases are ordinarily included in the pre-employment physical exam except for those employees who provide results of blood tests or immunization documentation from their own health care providers. Any vaccinations required for these diseases will be given at no cost in our Occupational Health office.
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