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Department: The Department of Comparative Medicine (DCM) is one of 12 basic science departments in the School of Medicine. The mission of the department is to advance knowledge and improve the health and welfare of humans and animals through excellent service support, biomedical research, and teaching. DCM is the central laboratory animal medicine resource at the University of Washington, supporting over 114,000 assignable square feet of animal facilities with an average daily census in excess of 100,000 animals across multiple species (e.g., rodents, rabbits, swine, amphibians and zebrafish). The department employs over 175 individuals who provide a comprehensive range of animal husbandry, veterinary, and laboratory services across numerous vivaria. The UW animal care program is accredited by AAALAC International and provides services to over 200 principal investigators. DCM faculty members, post-doctoral researchers, and residents conduct basic and clinical research on a wide range of subjects including, but not limited to, comparative aspects of infectious disease, aging, cancer biology and genetics.
The Department of Comparative Medicine has an outstanding opportunity for a Research Scientist/Engineer 1 to act as the laboratory manager for a molecular immunology lab focused on understanding the roles of specific proteins in the development and function of immune cells.
The purpose of our studies is to understand the functions of two proteins recently found to be mutated in humans with primary immunodeficiency disease. Studies involve utilizing mouse models with tissue-specific mutations to model human disease, and to define how loss-of-function mutations alter the development and functions of immune cells. For references to laboratory manuscripts, please see Park et al Journal of Experimental Medicine PMID 19015308; Habib et al Journal of Cell Biology PMID 17998397; Park et al Immunity PMID 22608497; Reyes et al PNAS PMID 25548157; Iwata et al., Journal of Immunology PMID 277521345; Suwankitwat et al., Journal of Experimental Medicine PMID 33600594).
DUTIES AND RESPONSIBILITIES
Acting as the laboratory manager for a molecular immunology lab focused on understanding the roles of specific proteins in the development and function of immune cells.
Overseeing the maintenance of a large transgenic mouse colony, assisting with experiments.
Setting up breeding pairs, obtaining tissue samples, placing ear tags, making DNA, running PCRs, separating PCR products using agarose gel electrophoresis, updating an excel file with mouse genotypes
Involved in collaborative and/or independent research projects.
Learning research techniques including flow cytometry, immunoblotting, realtime PCR, RNAseq (and other genomic techniques), proteomics, metabolomics, fluorescent microscopy, and more.
Overseeing and training student helpers, assisting with general laboratory organization, ordering supplies, ensuring lab members are trained in occupational health and biosafety.
Bachelor's degree in biology or related field.
Up to one year of work-related experience.
Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.
Demonstrated experience working with mice, PCR, and making DNA.
Highly organized and detail oriented.
Ability to work well in a team environment.
Demonstrated ability to teach students.
Excellent communication skills.
Demonstrated experience in Microsoft Excel.
Experience with flow cytometry, immunoblotting, and realtime PCR desirable.
Application Process: The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.
Founded in 1861, the University of Washington is one of the oldest public institutions in the west coast and one of the preeminent research universities in the world. The University of Washington is a multi-campus university comprised of three different campuses: Seattle, Tacoma, and Bothell. The Seattle campus is made up of sixteen schools and colleges that serve students ranging from an undergraduate level to a doctoral level. The university is home to world-class libraries, arts, music, drama, and sports, as well as the highest quality medical care in Washington State and a world-class academic medical center. The teaching and research of the University’s many professional schools provide undergraduate and graduate students the education necessary toward achieving an excellence that will serve the state, the region, and the nation. As part of a large and diverse community, the University of Washington serves more students than any other institution in the Northwest.